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The Hippo signaling pathway, also known as the Salvador/Warts/Hippo (SWH) pathway, is regulated by various stimuli, such as G-protein coupled receptor signaling, cellular energy status, mechanical stress, etc. Its name is derived from one of its key signaling components-the protein kinase Hippo (Hpo) in fruit fly. Tissue overgrowth is the major cause for mutations in this gene.
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